There are at least 21 cities named Santo Domingo in the entire world. The following map and table contain general information about these cities.
| # | Country | Region | City | Coordinates |
|---|---|---|---|---|
| 1 | Mexico | Guanajuato | Santo Domingo | 20.516, -101.229 |
| 2 | Mexico | Guerrero | Santo Domingo | 18.402, -100.729 |
| 3 | Mexico | San Luis Potosí | Santo Domingo | 22.283, -100.17 |
| 4 | Mexico | Chiapas | Santo Domingo | 15.031, -92.104 |
| 5 | Mexico | Yucatán | Santo Domingo | 20.6, -90.117 |
| 6 | Mexico | Campeche | Santo Domingo | 17.999, -89.377 |
| 7 | Nicaragua | Chontales Department | Santo Domingo | 12.264, -85.082 |
| 8 | Costa Rica | Heredia Province | Santo Domingo | 10.064, -84.155 |
| 9 | Panama | Chiriquí Province | Santo Domingo | 8.51, -82.714 |
| 10 | Cuba | Villa Clara Province | Santo Domingo | 22.587, -80.243 |
| 11 | Panama | Los Santos Province | Santo Domingo | 7.749, -80.241 |
| 12 | Peru | Piura | Santo Domingo | -5.029, -79.876 |
| 13 | Peru | La Libertad | Santo Domingo | -8.105, -78.911 |
| 14 | Colombia | Antioquia | Santo Domingo | 6.473, -75.165 |
| 15 | Venezuela | Mérida | Santo Domingo | 8.861, -70.695 |
| 16 | Dominican Republic | Nacional | Santo Domingo | 18.472, -69.892 |
| 17 | Puerto Rico | Peñuelas | Santo Domingo | 18.063, -66.752 |
| 18 | Philippines | Ilocos | Santo Domingo | 17.635, 120.411 |
| 19 | Philippines | Central Luzon | Santo Domingo | 14.991, 120.743 |
| 20 | Philippines | Cagayan Valley | Santo Domingo | 17.16, 121.752 |
| 21 | Philippines | Bicol Region | Santo Domingo | 13.42, 123.449 |